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KMID : 0385219910010020162
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Korean Journal of Gerontology
1991 Volume.1 No. 2 p.162 ~ p.167
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Antipoisoning effects of vitamin E and Selenium against (H2O2) and (CCl4)
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Ham Young-Kook
Jeong Jae-U
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Abstract
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The roles of vitamin E ( -tocopherol) in membrane lipids and selenium, which is a metal in glutathione peroxidase as an important regulatory enzyme of the biological redox system, are considered to be in their antioxidant functions. In this experiment, the effects of vitamin E and/or selenium (Se)-supplementation on the poisoning induced by H2O2 or CCl4-injection were tested in various experimental parameters after dividing the rats into 8groups (n=12). In the thiobarbituric acid (TBA) test after H2O2-poisoning, the values of vitamin E and the Se-group were sufficiently lower than those of the control. In the case of CCl4-injection, the TBA values of the liver showed the lowest in the groups of vitamin E alone or vitamin E and Se. After H2O2-injection, the activity of catalase in the red blood cell was significantly increased in the vitamin E-supplemented group. However, in the case of CCl4-injection, the activity was highly increased in the groups of Se and Se with vitamin E. The activity of glutathione peroxidase in whole blood also showed an overall increase, but there were not any differences between vitamin E- and Se-group. The high increase of glutathione peroxidase (GSHPx) activity in the vitamin E and Se-group may be due to their synergic effect. On the hepatic mitochondrial respiration, the two groups did not show any significant differences, but the O2- consumption of the groups was rather lower than that of the control. Thus, the results showed that vitamin E and Se suppress the lipid peroxidation of cell membrance as antioxidants in vivo and have increasing effects of the related enzyme activities. Although vitamin E showed relatively more antioxidant effect than Se, the mixed group of vitamin E and Se showed higher antipoisoning effect than vitamin E- or Se-group, respectively.
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KEYWORD
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Vit. A와 E, antioxidants, lipid peroxidation, redox system enzyme
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